Featured publications
Men Y, Higashimori H, Reynolds K, Tu L, Jarvis R, Yang Y. 2022. Functionally Clustered mRNAs Are Distinctly Enriched at Cortical Astroglial Processes and Are Preferentially Affected by FMRP Deficiency. J Neurosci. 42(29): 5803-5814. Abstract
Kim G, Chen X, Yang Y. 2022. Pathogenic Extracellular Vesicle (EV) Signaling in Amyotrophic Lateral Sclerosis (ALS). Neurotherapeutics. Abstract
Yelick J, Men Y, Jin S, Seo S, Espejo-Porras F, Yang Y. 2020. Elevated exosomal secretion of miR-124-3p from spinal neurons positively associates with disease severity in ALS. Experimental Neurology. Abstract
Men Y, Ye L, Risgaard R, Promes V, Zhao X, Paukert M, Yang Y. 2020. Astroglial FMRP deficiency cell-autonomously up-regulates miR-128 and disrupts developmental astroglial mGluR5 signaling. PNAS. Abstract | PDF
Men Y, Yelick J, Jin S, Tian Y, Chiang MSR, Higashimori H, Brown E, Jarvis R, Yang Y. 2019. Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS. Nat Commun. 10(1): 4136. Abstract | PDF
Yang Y, Jackson R. 2019. Astrocyte identity: evolutionary perspectives on astrocyte functions and heterogeneity. Curr Opin Neurobiol. 56: 40-46. Abstract | PDF
Morel L, Men Y, Chiang MSR, Tian Y, Jin S, Yelick J, Higashimori H, Yang Y. 2019. Intracortical astrocyte subpopulations defined by astrocyte reporter Mice in the adult brain. Glia Epub ahead of print. Abstract | PDF
Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH. 2018. Kir4.1-dependent astrocyte-fast motor neuron interactions are required for peak strength. Neuron 98: 306-319. Abstract | PDF
Wang F, Han J, Higashimori H, Wang J, Liu J, Tong L, Yang Y, Dong H, Zhang X, Xiong L. 2018. Long-term depression induced by endogenous cannabinoids produces neuroprotection via astroglial CB1R after stroke in rodents. J Cereb Blood Flow Metab. Epub ahead of print. Abstract | PDF
Morel L, Chiang MSR, Higashimori H, Shoneye T, Iyer LK, Yelick J, Tai A, Yang Y. 2017. Molecular and functional properties of regional astrocytes in the adult brain. J Neurosci. 37: 8706-8717. Abstract | PDF
Ng FS, Sengupta S, Huang Y, Yu AM, You S, Roberts MA, Iyer LK, Yang Y, Jackson FR. 2016. TRAP-seq profiling and RNAi-based genetic screens identify conserved glial genes required for adult Drosophila behavior. Front Mol Neurosci. 9: 146. Abstract | PDF
Higashimori H, Schin CS, Chiang MS, Morel L, Shoneye TA, Nelson DL, Yang Y. 2016. Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to Fragile X Syndrome phenotypes in vivo. J Neurosci. 36: 7079-7094. Abstract | PDF
Clasadonte J, Morel L, Barrios-Camacho CM, Chiang MS, Zhang J, Iyer L, Haydon PG, Yang Y. 2016. Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy. Neurobiol Dis. 91: 315-325. Abstract | PDF
Ng SK, Higashimori H, Tolman M, Yang Y 2015. Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis. Exp Neurol. 267: 115-122. Abstract | PDF
Armbruster M, Hampton D, Yang Y, Dulla CG. 2014. Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion. Front Cell Neurosci. 8:277. Abstract | PDF
Andresen L, Hampton D, Taylor A, Morel L, Yang Y, Maguire J, Dulla CG. 2014. Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation. Neurobiol Dis. 71: 305-316. Abstract |
Morel L, Higashimori H, Tolman M, Yang Y. 2014. VGluT1+ neuronal glutamatergic signaling regulates postnatal developmental maturation of cortical protoplasmic astroglia. J Neurosci. 34: 10950-10962. Abstract | PDF
Kawamata H, Ng SK, Diaz N, Burstein S, Morel L, Osgood A, Sider B, Higashimori H, Haydon PG, Manfredi G, Yang Y. 2014. Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis. J Neurosci. 34: 2331-2348. Abstract | PDF
Yang Y, Higashimori H, Morel L. 2013. Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders. J Neurodev Disord. 5 : 22. Abstract | PDF
Morel L, Regan M, Higashimori H, Ng SK, Esau C, Vidensky S, Rothstein J, Yang Y. 2013. Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1. J Biol Chem. 288: 7105-7116. Abstract | PDF
Higashimori H, Morel L, Huth J, Lindemann L, Dulla C, Taylor A, Freeman M, Yang Y. 2013. Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the Fragile X mouse. Hum Mol Genet. 22: 2041-2054. Abstract | PDF