Featured publications

Men Y, Higashimori H, Reynolds K, Tu L, Jarvis R, Yang Y. 2022. Functionally Clustered mRNAs Are Distinctly Enriched at Cortical Astroglial Processes and Are Preferentially Affected by FMRP Deficiency. J Neurosci. 42(29): 5803-5814. Abstract

Kim G, Chen X, Yang Y. 2022. Pathogenic Extracellular Vesicle (EV) Signaling in Amyotrophic Lateral Sclerosis (ALS). Neurotherapeutics. Abstract

Jin S, Higashimori H, Schin C, Tamashiro A, Men Y, Chiang M, Jarvis R, Cox D, Feig L, Yang Y. 2021. Astroglial FMRP modulates synaptic signaling and behavior phenotypes in FXS mouse model. Glia. Abstract

Yelick J, Men Y, Jin S, Seo S, Espejo-Porras F, Yang Y. 2020. Elevated exosomal secretion of miR-124-3p from spinal neurons positively associates with disease severity in ALS. Experimental Neurology. Abstract

Men Y, Ye L, Risgaard R, Promes V, Zhao X, Paukert M, Yang Y. 2020. Astroglial FMRP deficiency cell-autonomously up-regulates miR-128 and disrupts developmental astroglial mGluR5 signaling. PNAS. AbstractPDF

Jarvis R, Tamashiro-Orrego A, Promes V, Tu L,  Shi J, Yang Y. 2020. Cocaine Self-administration and Extinction Inversely Alter Neuron to Glia Exosomal Dynamics in the Nucleus Accumbens. Front. Cell. Neurosci. 13:581. AbstractPDF

Men Y, Yelick J, Jin S, Tian Y, Chiang MSR, Higashimori H, Brown E, Jarvis R, Yang Y. 2019. Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS. Nat Commun. 10(1): 4136. AbstractPDF

Yang Y, Jackson R. 2019. Astrocyte identity: evolutionary perspectives on astrocyte functions and heterogeneity. Curr Opin Neurobiol. 56: 40-46. AbstractPDF

Morel L, Men Y, Chiang MSR, Tian Y, Jin S, Yelick J, Higashimori H, Yang Y. 2019. Intracortical astrocyte subpopulations defined by astrocyte reporter Mice in the adult brain. Glia Epub ahead of print. AbstractPDF

Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH. 2018. Kir4.1-dependent astrocyte-fast motor neuron interactions are required for peak strength. Neuron 98: 306-319. AbstractPDF

Wang F, Han J, Higashimori H, Wang J, Liu J, Tong L, Yang Y, Dong H, Zhang X, Xiong L. 2018. Long-term depression induced by endogenous cannabinoids produces neuroprotection via astroglial CB1R after stroke in rodents. J Cereb Blood Flow Metab. Epub ahead of print. AbstractPDF

Morel L, Chiang MSR, Higashimori H, Shoneye T, Iyer LK, Yelick J, Tai A, Yang Y. 2017. Molecular and functional properties of regional astrocytes in the adult brain. J Neurosci. 37: 8706-8717.  AbstractPDF

Ng FS, Sengupta S, Huang Y, Yu AM, You S, Roberts MA, Iyer LK, Yang Y, Jackson FR. 2016. TRAP-seq profiling and RNAi-based genetic screens identify conserved glial genes required for adult Drosophila behavior. Front Mol Neurosci. 9: 146.  AbstractPDF

Higashimori H, Schin CS, Chiang MS, Morel L, Shoneye TA, Nelson DL, Yang Y. 2016. Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to Fragile X Syndrome phenotypes in vivo. J Neurosci. 36: 7079-7094. AbstractPDF

Clasadonte J, Morel L, Barrios-Camacho CM, Chiang MS, Zhang J, Iyer L, Haydon PG, Yang Y. 2016. Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy. Neurobiol Dis. 91: 315-325. AbstractPDF

Ng SK, Higashimori H, Tolman M, Yang Y 2015. Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis. Exp Neurol. 267: 115-122. AbstractPDF

Armbruster M, Hampton D, Yang Y, Dulla CG. 2014. Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion. Front Cell Neurosci. 8:277. AbstractPDF

Andresen L, Hampton D, Taylor A, Morel L, Yang Y, Maguire J, Dulla CG. 2014. Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation. Neurobiol Dis. 71: 305-316. Abstract |

Morel L, Higashimori H, Tolman M, Yang Y. 2014. VGluT1+ neuronal glutamatergic signaling regulates postnatal developmental maturation of cortical protoplasmic astroglia. J Neurosci. 34: 10950-10962. AbstractPDF

Kawamata H, Ng SK, Diaz N, Burstein S, Morel L, Osgood A, Sider B, Higashimori H, Haydon PG, Manfredi G, Yang Y. 2014. Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis. J Neurosci. 34: 2331-2348. AbstractPDF

Yang Y, Higashimori H, Morel L. 2013. Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders. J Neurodev Disord. 5 : 22. AbstractPDF

Morel L, Regan M, Higashimori H, Ng SK, Esau C, Vidensky S, Rothstein J, Yang Y. 2013. Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1. J Biol Chem. 288: 7105-7116. AbstractPDF

Higashimori H, Morel L, Huth J, Lindemann L, Dulla C, Taylor A, Freeman M, Yang Y. 2013. Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the Fragile X mouse. Hum Mol Genet. 22: 2041-2054. AbstractPDF

Higashimori H, Yang Y. 2012. Imaging analysis of neuron to glia interaction in microfluidic culture platform (MCP)-based neuronal axon and glia co-culture system. J Vis Exp. pii: 4448. AbstractPDF