Current Team Members
Yongjie Yang
Professor of Neuroscience
BA, Marine Biology, Ocean University of China
MS, Genetics, Ocean University of China
PhD, Neuroscience, Iowa State University
Postdoctoral Training, Johns Hopkins University
yongjie.yang@tufts.edu
Rashed Alananzeh
Research Technician
BA, Biology, Boston University, Boston, MA
rashed.alananzeh@tufts.edu
Rashed graduated from Boston University in January of 2021 with honors of Magna Cum Laude. He received his bachelor of arts degree in Biology (Specialization in Cellular, Molecular, and Genetics). He is planning to apply to graduate school to start in the Fall of 2023. He enjoys immersing himself in the community and connecting with new individuals. Rashed is a hands-on mechanic and likes to fix and work on cars in his free time. He also enjoys reading and writing poetry.
Marcela Bertolio
Post-Doctoral Scholar
PhD, Molecular Biology & Biotechnology, National University of San Martin, Buenos Aires, Argentina
Marcela.Bertolio@tufts.edu
Astroglia plays active and diverse roles in modulating neuronal/synaptic functions in the CNS. How these astroglial functions are regulated, especially by neuronal signals, remains largely unknown. My research focus on investigating the exosome RNA and non-exosome RNA-mediated neuron to astroglial communication mechanisms and how alteration of these mechanisms may contribute to neurological diseases.
Xuan Chen
Post-Doctoral Scholar
MD, PhD, Neurology, Xiangya Medical College, Central South University, Changsha, China
Xuan.Chen@tufts.edu
After graduation from Medical College, I practiced as a neurologist at clinic for 5 years. To fulfill my curiosity in the mystic brain network, I switched my interests from clinic to neuroscience. I’m fascinated by the smart soldiers—Microglia and their multifaceted roles in maintaining the homeostasis or triggering the disease progression in the brain. My research mainly focuses on understanding the signal transmission via exosomes between microglia and other neural cells of the brain in the context of neurodegenerative diseases.
Jingwen Hu
Master’s Student
B Eng, Pharmaceutical Engineering, Southwest Jiaotong University, Chengdu, China
Jingwen.Hu@tufts.edu
I am studying microglia immune response in neurodegenerative disease. My research is focusing on the role of Clec7a in mediating the microglial immune response in ALS.
Shijie Jin
Research Associate
MBBS, Medicine, Liaoning Medical University, Jinzhou, China
PhD, Medicine, Graduate School of Medicine, Nagoya University, Nagoya, Japan
shijie.jin@tufts.edu
Most of my studies have focused on the role of glial cells in neuro-immunological diseases and neurodegenerative diseases. Recently I worked on “Cell type specific exosomes signaling in disease spreading of ALS” project. In the current study, we developed a cell-type specific exosome reporter mouse line (hCD63-GFP conditional knock-in, CD63-CKI) in which a GFP-fused CD63 can be induced in a particular cell type when bred with the cell-type specific Cre driver mice or stereotaxic injection of viral vectors expressing Cre recombinase. By employing this mouse tool, we found that exosomes are widely present in the CNS, and that astrocyte-secreted exosomes are significantly changed in SOD1 (G93A) mouse model of ALS. Our ultimate goal is to clarify the role of cell type specific exosomes and create novel beneficial therapeutic strategies for neurodegenerative disease.
Qiyi Li
Master’s Student
Qiyi.Li@tufts.edu
Maria Majid
Master’s Student
BS, Cell & Developmental Biology, University of Rochester, Rochester, NY
MS Candidate, Biomedical Sciences, Tufts University, Boston, MA
Maria.Majid@tufts.edu
I received my B.S. in Cell and Developmental Biology from the University of Rochester in 2019, after which I worked as a research technologist at Johns Hopkins School of Medicine. I returned to school at Tufts School of Medicine in 2021 where I am currently completing my M.S. in Biomedical Sciences while applying to medical school. I’m studying how different isoforms of FMR1 influence behavior in FMR1 KO mice for my thesis project. Outside of the lab, I enjoy playing squash, dancing, and mentoring students!
Francesca Mowry
Postdoctoral Scholar
Francesca.Mowry@tufts.edu
Kathryn Reynolds
Postdoctoral Scholar
PhD, Neuroscience, McMaster University, Hamilton ON, Canada
MSc, Molecular and Cellular Biology (Collaborative Neuroscience Specialization), University of Guelph, Guelph ON, Canada
BSc, Biomedical Science, University of Guelph, Guelph ON, Canada
Kathryn.Reynolds@tufts.edu
I received my PhD in Neuroscience from McMaster University in 2021, where I studied astrocyte purinergic signalling in Fragile X Syndrome (FXS). I am continuing my FXS research in the Yang lab by investigating developmental Fmr1 isoform-specific regulation of translation and behaviour, as well as astroglial-specific changes in microRNA levels. Outside of the lab, you’re most likely to find me exploring New England with my camera.
Caroline Reynolds
PhD Student
BS, Biological Sciences, George Washington University, Washington, DC
Caroline.Reynolds@tufts.edu
After studying Biology, Public Health and Sustainability at GW, I worked as a Research Assistant at UTHealth Science Center Houston and next as a Lab Technician at Cleveland Clinic. I am currently completing my PhD in Neuroscience in Dr. Yang’s lab at Tufts University. Here, I am investigating how astrocytic exosomes are able to efflux from the brain and enter the periphery’s circulation as well as determining how these vesicles are able to stimulate the peripheral immune system, and how these pathways are altered in late-onset Alzheimer’s Disease animal models.