Opportunities

The Yang Lab is always interested in highly motivated individuals eager to study the broad research area of Neuron-Glia communication.

Feel free to contact Dr. Yongjie Yang for more information.

Postdoctoral Fellow Positions Available

Two postdoctoral fellow/research associate positions supported by NIH funding are available until filled in the laboratory of Professor Yongjie Yang in the Department of Neuroscience at Tufts University School of Medicine (Boston, MA) to study (astro)glia to neuron communication mechanisms in neurological diseases.

The Yang lab primarily studies neuron to glia signaling and pathogenic roles of glial mechanisms in neurological diseases/disorders. The lab employs novel genetically modified mouse and viral tools, in combination with primary glia and neuronal cultures, cell biological imaging, electrophysiological, and biochemical/molecular techniques.

In recent years, new studies from our lab and others have shown the emerging roles of secreted endosome-derived exosome signaling in physiological and pathological communication between neurons and (astro)glial cells. Our lab has developed new tools for in vivo mechanistic investigations (Nat. Comm., 2019) into how this pathway is involved in the pathological development of neurological diseases (mainly Amyotrophic Lateral Sclerosis and Alzheimer’s Disease).

In addition to the role of astrocyte to neuron communication in neurodegenerative diseases, we have also investigated developmental astroglial functions and their implication in Fragile X Syndrome (FXS), a neurodevelopmental disorder. We have established conditional Fmr1 deletion models for studying the role of Fmr1 in astrocytes, as a model to better understand how astrocytes are implicated in neurodevelopmental disorders. We have also identified new miR-based mechanisms and mRNA targets that are regulated by FMRP in astrocytes (PNAS, 2020).

Candidates who are interested in glia, especially glia to neuron communication, and their roles in neuropathological conditions are encouraged to apply. It is expected that the candidate should have a recent PhD (less than 2 years) in Neuroscience or a related discipline (Biochemistry/Cell Biology/Genetics) and is able to communicate well with others. The potential new postdoc candidate can choose to study either of the two research areas described above.

To apply, please send a CV (via e-mail) including all past education and training, a brief description of research interests, list of publications, other scientific activities, and names and e-mail addresses of three references to Dr. Yongjie Yang at: Yongjie.Yang@tufts.edu,

Tufts University School of Medicine is an Equal Opportunity Affirmative Action Employer. Women and minorities are encouraged to apply.

Useful links:

RESEARCH

Alzheimer’s association:

https://www.alz.org/

ALS association:

http://www.alsa.org/

https://www.packardcenter.org/index.html

National Fragile X Foundation:

https://fragilex.org/

miRNA data base:

http://mirbase.org/

Micro RNA to gene:

http://www.targetscan.org/vert_72/

Exosome database:

http://www.exocarta.org/

https://www.exosome-rna.com/

Gene Expression:

http://www.gensat.org/index.html

Allen Brain Atlas:

http://portal.brain-map.org/

Human protein atlas:

https://www.proteinatlas.org/

Extracellular Vesicle Database:

http://evpedia.info/

Fluorescent Protein Database:

https://www.fpbase.org/

TUFTS

Tufts University:
tufts.edu

Tufts Health Plan:
tuftshealthplan.com

BOSTON

Visiting Boston:
boston.gov/visiting-boston

Traveling around Boston:
mbta.com